When rising PSA means prostate cancer patient is in the future ...

When prostate cancer PSA means increase is the growing level of PSA (prostate specific antigen) in man?s FutureScienceDaily (May 18, 2011) of the patient for several years ? which was seen as a possible warning sign of prostate cancer-recently came under fire as a screening test because it requires sometimes biopsies which are to be normal.See also:Health & MedicineHealthUrologyProstate HealthDiseases of CancerMen of the prostate and medicinereferenceConditionsPersonalized UrologySaturated fatProstate cancerMetastasis

A new study, however, almost 70 percent of men who had increasing levels of PSA and biopsies normal later in the end have been diagnosed with prostate cancer, according to research from Northwestern University?s Feinberg School of Medicine. The trend of a PSA level for several years is called the PSA velocity.

?Our results show a high and growing level of PSA or speed should lead a clinician to follow more closely a patient, even if he has a negative biopsy,? said lead investigator William Catalona, M.D., Director of the prostate cancer program at the University Clinic, Robert h. Lurie Comprehensive Cancer Center of Northwestern. ?A negative biopsy is not the end of the road.?

The results were presented on May 18, at the American Urological Association 2011 Annual Meeting. Catalona is a Professor of Urology at the Feinberg School and a urologist at Northwestern Memorial Hospital.

PSA is a substance which elevated levels may indicate prostate cancer, but can also be caused by inflammation of the prostate or enlargement or other conditions. Catalona, known as the father of PSA screening, was the first to show in 1991 that a simple blood test to measure the levels of PSA may be used to detect prostate cancer.

For the study, Northwestern researchers examined in their database to the history of 97 patients with a growing trend PSA (or speed), which had a negative biopsy. Researchers have found 66 percent of patients were eventually diagnosed with prostate cancer, 20 percent had a benign prostatic, 8 percent had protatitis and 6 percent had precancerous lesions.

?This underlines the importance of using the PSA trend individual patient, when deciding whether to pursue a prostate biopsy,? said co-investigator Gregory Auffenberg, M.D., a Urology resident at the Feinberg School. ?It is not enough to look at only a single value PSA when historical data are also available.?

The research was partly supported by the Foundation, the prostate Urologic Research Grant and subsidy SPORES Lurie Cancer Center.

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